Sildenafil Citrate Rescues Fetal Growth in the Catechol- O -Methyl Transferase Knockout Mouse Model
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چکیده
منابع مشابه
Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model.
Preeclampsia and fetal growth restriction are responsible for the majority of maternal and perinatal morbidity and mortality associated with complicated pregnancies. Although their etiologies are complex and multifactorial, both are associated with increased uterine artery resistance. Sildenafil citrate is able to rescue the dysfunction observed ex vivo in uterine arteries of women with preecla...
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متن کاملSildenafil Citrate in Fetal Growth Restriction
BACKGROUND Pregnancies with early onset fetal growth restriction have poor perinatal outcome. Sildenafil citrate (PDE -5 inhibitor) as a vasodilator increases utero-placental blood flow and potentiates fetal growth. CASE PRESENTATION In this study, a case was examined and Sildenafil was administered for her. It was found that Sildenafil improved the uterine blood flow with a favorable fetal o...
متن کاملsildenafil citrate in fetal growth restriction
background: pregnancies with early onset fetal growth restriction have poor perinatal outcome. sildenafil citrate (pde -5 inhibitor) as a vasodilator increases uteroplacental blood flow and potentiates fetal growth. case presentation: in this study, a case was examined and sildenafil was administered for her. it was found that sildenafil improved the uterine blood flow with a favorable fetal ou...
متن کاملSildenafil Citrate Increases Fetal Weight in a Mouse Model of Fetal Growth Restriction with a Normal Vascular Phenotype
Fetal growth restriction (FGR) is defined as the inability of a fetus to achieve its genetic growth potential and is associated with a significantly increased risk of morbidity and mortality. Clinically, FGR is diagnosed as a fetus falling below the 5(th) centile of customised growth charts. Sildenafil citrate (SC, Viagra™), a potent and selective phosphodiesterase-5 inhibitor, corrects ex vivo...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2012
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.111.186270